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KMID : 0617320000090010102
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Journal of Pharmacetical Sceiences Ewha Womans University
2000 Volume.9 No. 1 p.102 ~ p.107
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Expression of translationally controlled tumor protein mRNA in human colon cancer
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Chung, Sookhee
Kim, Miyoung/Choi, Won-Ja/Chung, June-Key/Lee, Kyunglim
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Abstract
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The translationally controlled tumor protein (TCTP) was first identified as a tumor-associated protein. Here we described the expression profile of TCTP mRNA using a panel of normal human tissues. We also investigated the cell-cycle-dependence expression of the TCTP mRNA using synchronized cultures of Saccahromyces cerevisiae. The TCTP gene was constantly expressed through the yeast cell cycle. The expression of TCTP mRNA from three human colon carcinoma cell lines and the tumors xenografted in a nude mouse was studied. Our data imply that the TCTP is a housekeeping gene and that its deregulation may be involved in the tumor development of colon carcinoma.
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